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Antibodies

For different products in the biopharmaceutical industry (e.g. monoclonal antibody, bispecific antibody, polyclonal antibody, ADC, fusion protein) and different culture modes (e.g. batch, fed-batch, perfusion, high-density N-1 culture, etc.), BioEngine has developed Eden series CHO Cell CD medium by using its huge formulation library and patented iBioG-Med development platform. This medium can support the high-density culture of CHO cells and the efficient production of therapeutic proteins, and the expression and quality of the protein products are comparable to global brands. Besides, BioEngine provides cell culture technical services, including medium formulation development and process optimization, to meet different quality requirements. The media of BioEngine have a large number of successful application cases for mainstream production cell lines such as CHO-K1, CHO-ZN, CHO-S, CHO DG44, HORIZON, etc.
Currently, BioEngine has served 60+ antibody/fusion protein projects, including 4 marketed product projects, 20+ phase I-II clinical projects, and 30+ IND projects.

Serving

Biosimilars and innovative drugs (Monoclonal antibody/multi-specific antibody/Mab fusion protein)

Traditional targets (CD20/HER2/PD1 etc.) and new targets (CD38/IL6 etc.)

*The statistical data as of June 2022.
Typical Cases
No.UpdateAntibody typeCulture methodFeatures
01 Marketed Antibody fusion protein Traditional fed-batch 6-fold increase in titer
CQAs comparable with the RLD
02 BLA Monoclonal antibody Traditional fed-batch 3-fold increase in titer
CQAs comparable with the RLD
03 Phase III clinical trial Monoclonal antibody High density fed-batch 2-fold increase in titer
Manufacturing process change
04 IND Tetra-specific antibody Traditional fed-batch 3-fold increase in titer
Meet CQA requirements
05 IND application in both China and the US Bispecific antibody Perfusion

A 12-fold increase in yield compared

with traditional fed-batch process

Let us contact you

We have a professional technical team to provide high quality one-stop cell culture service from process development
and optimization, medium formulation design to medium processing and manufacturing for all biopharmaceutical companies.

If you have any question, please click "Quick Message" and leave your message,  we will reply to you as soon as possible.
If anything urgent, please call (86)21-68582660-2792.

BioEngine

3F&4F, Building 3, Lane 396, Lvzhou Ring Road, Minhang District, Shanghai, PRC

(86)21-68582660-2792

globalsales@bio-engine.com.cn

Work hours:9:00-17:00